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Liposomal, gel-like phthalocyanine composition for photodynamic therapy of tumor diseases and process for preparing thereof
Liposomal, gel-like phthalocyanine composition for photodynamic therapy of tumor diseases and process for preparing thereof
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机译:用于肿瘤疾病的光动力治疗的脂质体,凝胶状酞菁组合物及其制备方法
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摘要
The liposomal gel phthalocyanine preparation for photodynamic therapy of cancer and other diseases is formed by a set of lecithin liposomes with incorporated hydrophobic active agent, selected from the group consisting of hydroxy aluminum, aluminum, zinc, silicon or organosilicate, or hydrophobic metal-free phthalocyanine mixed in a 10: 1 to 1 ratio : 10 with a round pharmacy gel. The added active ingredient can be treated by coating with glucose or other sugars, polyethylene glycol or other polymers, lecithin, or NaCl or other salt suitable for pharmacology. The preparation is that the lecithin at a concentration of 1 to 40 mg per ml of fluid is fluidized in a microfluidizer in the appropriate chamber to a final particle size of less than 1000 nm at a temperature greater than 0 degC and a pressure of 50-200 MPa, followed by continuous mixing adds the active ingredient or the treated active ingredient in a ratio of between 5: 1 to 0.1: 1 in relation to lecithin, the resulting suspension being repeatedly fluidized on the microfluidizer in the respective smaller chamber to a final particle size of less than 500 nanometers at a pressure of 100 to 200 MPa at a temperature greater than 0 degC, the suspension obtained is then mixed with a circulating pharmaceutical gel in ratios of between 10: 1 to 1:10. Optionally, the lecithin is fluidized separately and the active agent also separately in the first step above, or the lecithin is processed by extrusion through 50-100 nm filters. The resulting suspension is then mixed with a circulating drug gel in a ratio of between 10: 1 to 1:10. The resulting liposome-containing gel with the incorporated active ingredient is applied to the topical tumors in dermatology or other tumors available to the light-guide light-guide in therapy.
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