1-oxa-3,9-diaza-spiro '5.5 undecan-2-one derivatives and their use as a neurokinin receptor antagonist

摘要

The invention relates to compounds of the general formulawherein(R1)n is independently from from each other halogen, lower alkyl or lower alkoxy;R2 is hydrogen, lower alkyl, lower halogen-alkyl, -(CH2)m-OH, -(CH2)m-NR2, -(CH2)mO-lower alkyl, -(CH2)m-C(O)-NR2, or is -(CH2)m-6-membered heteroaryl, optionally substituted by one or more lower alkoxy, -(CH2)m-5 or 6-membered not aromatic heterocyclyl, optionally substituted by hydroxy or lower alkyl;R is hydrogen or lower alkyl and may be the same or different in case of R2;n is 0, 1, or 2;m is 0, 1, 2, 3 or 4;and pharmaceutically acceptable acid addition salts thereof. These compounds have a good affinity to the NK-1 receptor and they are therefore suitable for the treatment of diseases, related to this receptor.