SYNTHETIC DOMAINS OF IMMUNOGLOBULIN, HAVING PROPERTIES OF BINDING AND DESIGNED MOLECULES IN SITES, DIFFERENT FROM HYPERVARIABLE AREAS

摘要

The method of constructing immunoglobulin containing at least one modification at the site of the structural loop of the immunoglobulin, and determining the binding of this immunoglobulin to the epitope of the antigen, and unmodified immunoglobulin is almost not associated with this epitope at least one section of the structural loop, modification of at least one nucleotide residue of at least one of these x structural loop regions, transferring this modified nucleic acid in an expression system, expression of the modified immunoglobulin, contacting the expressed modified immunoglobulin with an epitope, and determining whether the associated modified immunoglobulin with an epitope of data; as well as the modified immunoglobulins themselves.