A single acquisition diagnostic monitoring system for monitoring electrophysiology data and hemodynamic physiological data from a subject of interest. The system comprises a first module configured to receive the electrophysiology data via a plurality of first sensors coupled to the subject of interest. The system also comprises a second module configured to receive the hemodynamic physiological data via a plurality of second sensors coupled to the subject of interest. The system also comprises a base unit coupled to each module and configured to supply electrical power to each module, to receive the data from each module, and to synchronize the data from each module together. The system also comprises a processor coupled to the base unit and configured to receive the synchronized electrophysiology and hemodynamic physiological data from the base unit, combine the synchronized data into a single database, and transmit the synchronized processed data for further use.
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