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PHUMAN T2R RECEPTORS FOR ACETAMINOPHEN, RANITIDINE, STRYCHNINE, AND DENATONIUM, AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS
PHUMAN T2R RECEPTORS FOR ACETAMINOPHEN, RANITIDINE, STRYCHNINE, AND DENATONIUM, AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS
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机译:乙胺磷,雷尼替丁,金鸡菊碱和氘的PHUMAN T2R受体,以及鉴定人苦味调节剂的相关方法
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摘要
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R- associated bitter taste.
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