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COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY
COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY
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机译:通过CD14和类似Toll受体4信号通路调节细胞的组合物和方法
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摘要
Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for treatment of various disease states such as inflammation or autoimmune disease in mammalian subjects by modulating toll-like receptor 4 (TLR4) pathway signaling via CD 14 and a ligand. Transgenic non-human animals and methods for developing transgenic non-human animals are provided wherein the transgenic non-human animals comprise a loss-of-function mutation in the CD 14 gene.
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