NOVEL PROCESS FOR THE SYNTHESIS OF 5 - (4 - FLUOROPHENYL) - 1 - 2 - ((2R, 4R)- 4 - HYDROXY - 6 - OXO -TETRAHYDRO - PYRAN - 2 - YL) - ETHYL - 2 - ISOPROPYL- 4 - PHENYL - 1H - PYRROLE - 3 - CARBOXYLIC ACID PHENYLAMIDE

摘要

An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.