TOSYLATE SALT OF 6-(4-BROMO-2-CHLOROPHENYLAMINO)-7-FLUORO-N-(2-HYDROXYETHOXY)--3-METHYL-3H-BENZIMI DAZOLE-5-CARBOXAMIDE, MEK INHIBITOR USEFUL IN THE TREATMENT OF CANCER

摘要

The present invention relates to a tosylate salt of Compound 1 t and polymorphs thereof, in particular crystalline and amorphous forms of Compound 1 tosylate salt, and methods of preparation thereof. Pharmaceutical compositions containing these salts as active ingredient, their use in the manufacture of medicaments for use in the treatment and/or prophylaxis of proliferative disease states, such as cancer, in the human or animal body, and their use in methods for the treatment and/or prophylaxis of proliferative disease states, such as cancer, in the human or animal body are also described.