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anticancer bioconiugati acid ialuronico or its derivatives, obtainable by conjugation chemistry, direct or indirect, and their use in the pharmaceutical field
anticancer bioconiugati acid ialuronico or its derivatives, obtainable by conjugation chemistry, direct or indirect, and their use in the pharmaceutical field
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机译:可通过共轭化学方法直接或间接获得的抗癌生物融合酸阿尿酸或其衍生物,及其在制药领域的用途
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摘要
The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.
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