Therapeutic epitopes and uses thereof for treating and preventing coeliac disease

摘要

Disclosed is the use of at least one agent for a method of diagnosing or treating coeliac disease, where the agent is selected from: (a) a peptide comprising at least one epitope comprising a transglutaminase-deamidated QPQQXFP amino acid sequence wherein X = P, T or Q; and (b) an analogue of (a) which is capable of being recognised by a T cell receptor that recognises the epitope of (a) and which is not more than 50 amino acids in length; and (c) optionally, in addition to the agent selected from (a) and (b), a peptide comprising at least one epitope comprising a sequence selected from SEQ ID NO:1 and SEQ ID NO:2.