Pharmaceutical compositions containing a sinus node If current inhibitor i.e. ivabradine and an angiotensin-converting enzyme inhibitor i.e. perindopril for treating arterial hypertension

摘要

Disclosed is a pharmaceutical composition comprising a selective and specific sinus node If current inhibitor which is ivabradine, or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, or one of its hydrates, crystalline forms or addition salts with a pharmaceutically acceptable acid and an agent that inhibits angiotensin-converting enzyme (ACE-inhibitor). The preferred selective and specific sinus node If current inhibitor is ivabradine hydrochloride or one of its hydrates or crystalline forms and the preferred ACE-inhibitor is perindopril. These pharmaceutical compositions are suitable for the treatment of arterial hypertension.