Pharmaceutical composition comprising a QUATERNARY AMMONIUM COMPOUND and a Fluoroquinolone

摘要

Refers to a Pharmaceutical composition comprising: a) a QUATERNARY AMMONIUM COMPOUND of formula (iii) where R1, R2, R3 and R4 are each alkyl (C1 - C18) or optionally interrupted by, or Form A five to six members Heterocycles such as Pyridine or tiazolina X is sulfate, among others; has Logenuro, among others; being Preferred: CHLORIDES alkyldimethylbenzylammonium Chloride,Benzalkonium Chloride, Benzethonium Chloride, bromide N - Hexadecyl trimethylammonium chloride, N, 1-hexadecylpyridinium Chloride, among others; (b) a Fluoroquinolone such as ciprofloxacin, Enrofloxacin and marbofloxacin, pradofloxacino; and (c) a Di - or Trivalent metal cation such as Mg2 +.The QUATERNARY AMMONIUM COMPOUND prevents the precipitation of Fluoroquinolone in Solution suitable for parenteral Application