Derivatives of 3,4-dihydro - 2H - 1,4 benzo oxazine and thiazine as CETP inhibitors

摘要

Refers to compounds derived from 3,4-dihydro - 2H - [1,4] benzo oxazine and thiazine of formula (i), where l is Covalent or u; X is o or s; Q is aryl or heteroaryl (C6 C10) of 5 to 6 members, N and M are 0 to 3; r1 is alkyl (C1 - C10), alquenilo (C2 C10), among other option is phenyl or substituted At present, Halo; R2 is alkyl, Hydroxy, alkoxy or CN, (c1-c4) Halogenated,Among others; R3 is alkyl (c1-c4), alquenilo (c2-c4), among other alkyl; R4 (C1 - C10) is optionally substituted with 1 to 3 members of Halo, Hydroxy, Oxo, among others.Are selected: 1,1,1 trifluoro - - 3 - [3 - [3 - (1,1,2,2 - tetrafluoro - ethoxy) - phenyl] - 8 - (trifluoromethoxy) - phenyl) - 2,3 dihydro - benzo [1,4] oxazin - 4-yl] propan-2-ol, (3S) - 2.3 dihydro - 3 - [3 - (1,1,2,3 - tetrafluoroetoxi) phenyl] - 2 - [3 - (trifluoromethoxy) phenyl] - (trifluoromethyl) - 4H - 1.4 - benzoxazina - 4 - ethanol, among others. You. It also relates to a Pharmaceutical composition.These compounds are CETP inhibitors and are useful in the treatment of Atherosclerosis, Hyper LDL - cholesterol, dyslipidemia, diabetes, obesity, cardiovascular diseases and related