Coterapia constituted by a heterociclosulfamida benzofusionado derivative and one or several anticonvulsant agents and / or antilepticos

摘要

Refers to a combination Therapy or coterapia comprising: a) a heterociclosulfamida benzofusionado Derivative of formula (i) wherein R1 and R2 are independently h, Lower alkyl; R4 is H, alkyl, Bottom, is 1 to 2, R is a selected Group of 2 - (2,3 dihydro - benzo [1,4] dioxin ILO), 2 - (benzo [1,3] dioxolilo), 2 - (6 - Chloro - 2,3 dihydro - benzo [1,4] dioxinilo)Among others, are selected: (3,4-dihydro - 2H - benzo [b] [1,4] dioxepin - 3 - yl) methyl) sulfonamide, N - (2,3 Dihydro 1,4 - benzo [Dioxin] - 2 - (methyl) - sulfonamide, 2S) - (-) - N - (6 - chlorine - 2,3 Dihydro - benzo [1,4] dioxin - 2 - methyl) - sulfonamide, among others; and (b) one or several anticonvulsant agents and / or antilepticos Select Ionados: clobazam, carbamazepine, clonazepam, Ethosuximide, Lamotrigine, phenytoin, gabapentin,Among others. To be useful in the treatment of Epilepsy and Related Disorders