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USE OF POLYMORPHISMS IN HUMAN OATP-C ASSOCIATED WITH AN EFFECT ON STATIN PHARMACOKINETICS IN HUMANS IN STATIN THERAPY
USE OF POLYMORPHISMS IN HUMAN OATP-C ASSOCIATED WITH AN EFFECT ON STATIN PHARMACOKINETICS IN HUMANS IN STATIN THERAPY
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机译:多态性在人类OATP-C中的应用及其对他汀类药物治疗中他汀类药物药代动力学的影响
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摘要
This invention relates to use of polymorphisms in human OATP-C in statin therapy because they are associated with an effect on statin pharmacokinetics (PK) in humans, especially rosuvastatin pharmacokinetics. The invention also relates to the use of OATP-C polymorphisms in predicting the efficacy and safety of statins, whose uptake in to the liver is mediated by OATP-C, especially rosuvastatin.
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