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MANUFACTURING OF A RAPIDLY DISINTEGRATING PRESENTATION STARTING FROM A SOLID POWDER AND A STEP OF FREEZE DRYING
MANUFACTURING OF A RAPIDLY DISINTEGRATING PRESENTATION STARTING FROM A SOLID POWDER AND A STEP OF FREEZE DRYING
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机译:从固态粉末开始制造可快速分解的演示文稿,然后进行冷冻干燥
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摘要
The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into cavities of blister packs or moulds, the remaining components dissolved in water dosed and added to the powder to form a moistened, plasticized mass, frozen to below 20° C., and the water sublimed in high vacuum. In this way solid dosage forms are obtained with a similar porous structure as usually result from freeze drying processes, but the process requires much less water, which means considerably less time and less energy.
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