Normal;heading 1;heading 2;GLUCAGON-LIKE PEPTIDE 1 HETEROLOGOUS FUSION PROTEIN FOR THE PREPARATION OF A MEDICINE FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS

摘要

The present invention relates heterologous fusion protein comprising a first polypeptide fused to a second polypeptide wherein the first polypeptide is a GLP-1 compound (glucagon-like peptide 1) and the second polypeptide is selected from the group consisting of a) human albumin; b) human albumin analogs; and c) fragments of human albumin. These proteins have the effect of extending the in vivo half-life of the peptides. The invention relates as well to pharmaceutical composition comprising these fusion proteins and use of the heterologous fusion protein for the preparation of a medicine for treatment of non-insulin dependent diabetes mellitus as well as a variety of other conditions.