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Poly(ethylene glycol)-modified human growth hormone and use thereof
Poly(ethylene glycol)-modified human growth hormone and use thereof
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机译:聚乙二醇修饰的人类生长激素及其用途
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摘要
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. The present invention also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
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