METHOD FOR THE SYNTHESIS OF TRISODIUM PHOSPHONOFORMATE HEXAHYDRATE

摘要

THE PRESENT INVENTION RELATES TO A METHOD FOR THE SYNTHESIS OF FOSCARNET, I. E. TRISODIUM PHOSPHONOFORMATE HEXAHYDRATE, COMPRISING THE STEPS OF ADDING SODIUM HYDROXIDE TO WATER , HEATING THE AQUEOUS SODIUM HYDROXIDE SOLUTION TO 50°C, ADDING TRIETHYL PHOSPHONOFORMATE TO SAID SOLUTION AT 50°C, HEATING THE REACTION MIXTURE TO REFLUX FOR ABOUT 1 HOUR, COOLING OF THE REACTION MIXTURE AND FILTERING -OFF OF THE PRODUCT.