A METHOD FOR INHIBITING IMMUNOGLOBINENE IN IMMUNOGLOBINS IN THERAPY AND IN VIVO DIAGNOSTIC IMMUNOGLOBININE-INDUCED TOXICITY

摘要

The present invention provides a method for inhibiting immunoglobulin-induced toxicity resulting from immunotherapy in a subject comprising administering an immunoglobulin or Ig fusion protein molecule to the subject, the immunoglobulin molecule having a variable region and a constant region, the immunoglobulin molecule being modified prior to administration by inactivation of at least a portion of the constant region.