PHOSPHORYLATING EPITOPES FROM THE TAU PROTEIN FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER DISEASE

摘要

The invention relates to epitopes of the tau protein which are specifically occurring in a phoshorylated state in tau protein from Alzheimer paired helical filaments, to the use of protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to diagnostic compositions and methods for the diagnosis and/or monitoring of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein.