Phospho-tau SRM's - Multi-site phosphorylation assays for tau protein in pre-clinical models of Alzheimer's Disease and other neurological disorders

摘要

MS workflows have been established and are available to screen and quantify phosphorylation sites in tau. Phospho Tau SRM Assay v1 enables the simultaneous screening of four phosphorylation sites in tau isolated from pre-clinical materials. Further reiterations of the method will include additional sites of phosphorylation and provide improved sensitivity to extend the utility of these assays into clinical studies.