INHIBITORS OF N-TERMINAL KINASES C-JUN (JNK) AND OTHER KINASE PROTEINS.

摘要

A compound of formula I or II: (See formula) or a pharmaceutically acceptable salt thereof, where: each W is independently selected from nitrogen or CH; R 1, R 2 and R 3 are independently selected from OH, OCH3, OCH2CH3, NHCOMe, NH2, NH (C1-4 aliphatic group), N (C1-4 aliphatic group) 2, O (CH2) 2morpholin-4-yl , O (CH2) 2NH2, O (CH2) 2NH (C1-4 aliphatic group), O (CH2) 2N (C1-4 aliphatic group) 2, bromine, chlorine or fluorine; or (See formula) R 1 and R 2 or R 2 and R 3 taken together to form R 4 is a phenyl, cyclohexyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, thiazolyl, thiadiazolyl, pyrazolyl, isoxazolyl, indazolyl or substituted benzimidazolyl ring ; wherein said ring is substituted with 1-2 groups independently selected from chlorine, fluorine, bromine, methyl, ethyl, t-butyl, isopropyl, cyclopropyl, CF3, NH2, benzyl, benzyloxy, OH-, methylenedioxy, SO2NH2, phenoxy, O- pyridinyl, SO2fenilo, nitrophenoxy, aminophenoxy, S-dimethylpyrimidine, NH-phenyl, NH-methoxyphenyl, pyridinyl, aminophenyl, phenol, chloro-fluorophenyl, dimethylaminophenyl, CF3-phenyl, dimethylphenyl, chlorophenyl, fluorophenyl, methoxyphenoxy, chlorophenoxy, ethoxyphenoxy or fluorophenoxy; with the proviso that: said compound is different from a compound of formula III (See formula)