PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION BY LEGEND / RECEIVER OF TUMOR NECROSIS FACTOR.

摘要

Composition comprising a PRO364 polypeptide in admixture with a pharmaceutically acceptable carrier, and a cardiovascular, endothelial or angiogenic agent, or an angiostatic agent, wherein the PRO364 polypeptide: (1) comprises amino acids 1 to 241 as detailed in SEC. . ID No.: 3; or (2) comprises amino acids 26 to 241 as detailed in SEC. ID No.: 3; or (3) comprises amino acid residues Y to X as detailed in SEC. ID No.: 3, where Y is any one of amino acid residues 1 to 26, and X is any one of amino acid residues 157 to 167; or (4) has at least 80% sequence identity, either with a full-length PRO364 polypeptide having amino acid residues 1 to 241 as detailed in SEC. ID No.: 3, or an extracellular domain of the PRO364 polypeptide having amino acid residues Y to X as detailed in SEC. ID No. 3: where Y is any one of amino acid residues 1 to 26, and X is any one of amino acid residues 157 to 167.