HIV PEPTIDES OF CONSERVED REGIONS, TAT, REV AND WEF AND ITS APPLICATION AS FOR EXAMPLE COMPONENTS OF VACCINE.

摘要

Peptide derived from the HIV-1 regulatory protein, wherein said peptide comprises at least one amino acid sequence selected from the group of amino acid sequences: in which the chain amino acids have the following meanings; Xaa in position 1 of the peptide derivative is Met, Ser, Cys or none, Xaa in position 2 is Glu, Asp, Val, Ser or none, Xaa in position 3 is Trp, Tyr or Phe, Xaa in position 4 is Val or Ile , Xaa in position 5 is Ile, or Asn, Xaa in position 6 is Pro, His or Ala, Xaa in position 7 is Arg, Asn, Ser, Lys, Glu or Asp, Xaa in position 12 is Leu, Ile or Nle, Xaa in position 15 is Gly or Pro, Xaa in position 16 is Ser, Asn or Ala, Xaa in position 17 is Gln, Lys or Thr, Xaa in position 18 is Pro or His, Xaa in position 19 is Leu, Ile or Nle Xaa in position 20 is Thr, Ala or Ile, Xaa in position 21 is Ala, Pro, Asp or Val, Xaa in position 22 is Cys or Ser, Xaa in position 23 is Thr, Asn or Ser, Xaa in position 24 is Asn, Lys, Arg, Gln, Ala Pro or Thr, the terminal ends of the sequences may be free amino or carboxyl groups, amides, acyl, acetyls or salts thereof, two or more residues of Cys residues may be part of an intracatenary or interc disulfide bridge attenuator, a bridge -S- (CH2) pS- or a bridge - (CH2) p in which p = 1-8, optionally interrupted by one or more heteroatoms such as O, N and S and / or said peptide sequences They are immobilized on a solid support.