MORFOLINILO CONTAINING BENCIMIDAZOLS AS INHIBITORS OF THE REPLICATION OF RESPIRATORY SYNTHETIC VIRUSES.

摘要

A compound having the formula (See formula) An N-oxide, addition salt, quaternary amino, metal complex, or a stereochemically isomeric form thereof; where G is a direct bond or C1-10alkanediyl optionally substituted by one or more substituents individually selected from the group of substituents consisting of hydroxy, C1-6alkyloxy, Ar1C1-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio , HO (-CH2-CH2-O) n-, C1-6alkyloxy (-CH2-CH2-O) n- or Ar1C1-6alkyloxy (-CH2-CH2-O) n-; R1 is Ar1 or a monocyclic or bicyclic heterocycle selected from piperidinyl, piperazinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthyridinyl, 1H-imidazo [4,5-b] pyridinyl, 3H-imidazo [4,5-b] pyridinyl, imidazo [1,2-a] pyridinyl 2,3-dihydro-1,4-dioxino [2,3-b] pyridyl or a radical of the formula (See formula) where each of the mentioned monocyclic or bicyclic heterocycles can be optionally substituted by one or, when if possible, more like 2,3,4 or 5 substituents selected individually, from the group of substituents consisting of halo, hydroxy, amino, cyano, carboxyl, C1-6 alkyl, C1-6alkyloxy, C1- 6alkylthio, C1-6alkyloxyC1-6alkyl, Ar1, Ar1C1-6Alkyl, Ar1C1-6alkyloxy, hydroxyC1-6Alkyl, mono- or di (C1-6alkyl) amino, mono- or di (C1-6alkyl) aminoC1-6alkyl, polyhaloC1-6alkyl, C1-6alkylcarbonylamino, C1-6Al NR5c-, Ar1-SO2-NR5c-, C1-6alkyloxycarbonyl, -C (= O) -NR5cR5d, HO (-CH2-CH2-O) n-, halo (-CH2-CH2-O) n-, C1-6alkyloxy (-CH2-CH2-O) n-, Ar1C1-6alkyloxy (-CH2-CH2-O) n- and mono- or di (C1-6alkyl) amino (-CH2-CH2-O) n-; each n is independently 1, 2, 3 or 4; each m is independently 1 or 2; each p is independently 1 or 2; each t is independently 0, 1 or 2; Q is R7, pyrrolidinyl substituted by R7, piperidinyl substituted by R7 or homopiperidinyl substituted by R7 where R7 is C1-6 alkyl substituted by a heterocycle or R7 is C1-6 alkyl substituted by both an OR8 radical and a heterocycle, where the heterocycle mentioned It is selected from the group consisting of oxazolidine, thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, hexahydrooxazepine, hexahydrotiazepine-hexahydrotiazepine , 1,1-dioxo-hexahydrotiazepine; where each of the mentioned heterocycles can be optionally substituted by one or two substituents selected from the group consisting of C1-6 alkyl, hydroxyC1-6 alkyl, aminocarbonylC1-6 alkyl, hydroxy, carboxyl, C1-4alkyloxycarbonyl, aminocarbonyl, mono- or di (C1-4alkyl) aminocarbonyl, C1-4alkylcarbonylamino, aminosulfonyl and mono- or di (C1-4alkyl) aminosulfonyl; R8 is ...