DERIVATIVES OF 2-CARBAMIDA-4-FENIL-TIAZOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS.

摘要

Compound of the following formula (1): (See formula) in which: - (i) R1 is selected from the group consisting of H, halogen; (C1-C8) alkyl, (C1-C4) trifluoroalkyl, -OH, -O-(C1-C8) alkyl, -O-trifluoroalkyl (C1-C8), -O-cycloalkyl (C3-C10) (C1-) alkyl C8), -O-cycloalkyl (C3-C10), -O-CH2-CH = CH2, and alkylthio (C1-C4); - (ii) R2 is selected from the group consisting of H, halogen, -OH, (C1-C8) alkyl, trifluoroalkyl (C1-C4), per-fluoroalkyl (C1-C4), cycloalkyl (C3-C10), -O - (C1-C8) alkyl, -O-cycloalkyl (C3-C10) (C1-C8) alkyl, -O-cycloalkyl (C3-C10), -O-CH2-CH = CH2, and (C3-C8) alkyl (C1-C8) alkyl; - (iii) Y represents a hydrogen atom or a halogen; - (iv) R3 represents: a1) a group of formula - (CH2) pA in which p represents 0, 1, 2, 3 or 4 and: - when p represents 2, 3 or 4, A represents a group of formula : (See formula) or -NR4R5, in which ...