AN ANIMAL MODEL TO STUDY HORMONAL SIGNALING AND A METHOD OF SIGNALING MODULATION.

摘要

An animal that is not genetically modified that exhibits increased or decreased levels of a SOCS protein or a derivative or homologue of its own, in which the SOCS protein, in an animal without genetically altering, comprises a portion of protein interaction: molecule in position N-terminal with respect to an SOCS box, and said SOCS box comprises the amino acid sequence: in which: X 1 is L, I, V, M, A or P; X 2 is any amino acid residue; X 3 is P, T or S; X 4 is L, I, V, M, A or P; X 5 is any amino acid; X 6 is any amino acid; X 7 is L, I, V, M, A, F, Y or W; X 8 is C, T or S; X 9 is R, K or H; X 10 is any amino acid; X 11 is any amino acid; X 12 is L, I, V, M, A or P; X 13 is any amino acid; X 14 is any amino acid; X 15 is any amino acid; X 16 is L, I, V, M, A, P, G, C, T or S; [X i] n is a sequence of n amino acids in which n is 1 to 50 amino acids and in which the sequence X i can comprise the same or different amino acids selected from any amino acid residue; X 17 is L, I, V, M, A or P; X 18 is any amino acid; X 19 is any amino acid; X 20 is L, I, V, M, A or P; X 21 is P; X 22 is L, I, V, M, A, P or G; X 23 is P or N; [X j] n is a sequence of n amino acids in which n is 0 to 50 amino acids and in which X j can comprise the same or different amino acids selected from any amino acid residue; X24 is L, I, V, M, A or P; X 25 is any amino acid; X 26 is any amino acid; X 27 is Y or F; X 28 is L, I, V, M, A or P. and wherein said SOCS protein is SOCS-2 and comprises the amino acid sequence set forth in SEQ ID NO: 2 or an amino acid sequence having at least 60 % similarity with her.