STEREOSELECTIVE MICROBIAL REDUCTION FOR THE PREPARATION OF 1-(4-FLUOROPHENYL)-3(R)-3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL)-4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

摘要

A process for the stereoselective microbial reduction of compound of formula(II) to compound of formula (I) comprising addingcompound of formula (II) to a medium, medium and buffer, medium and solvent,or medium and a mixture of buffer and solvent containinga microorganism, preferably Rhodococcus fascians ATCC No.202210 or fungalisolate Geotrichum candidum ATCC No. 74487, incubatingthe resulting mixture, and isolating a hydroxy compound of formula (I), isdescribed. The compound of formula (I) is a serum cholesterollowering agent.