STEREOSELECTIVE MICROBIAL REDUCTION FOR THE PREPARATION OF 1-(4-FLUOROPHENYL)-3(R)-¬3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL) -4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

摘要

A process for the stereoselective microbial reduction of compound of formula (II) to compound of formula (I) comprising adding compound of formula (II) to a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solvent containing a microorganism, preferably Rhodococcus fascians or fungal isolate Geotrichum candidum, incubating the resulting mixture, and isolating a hydroxy compound of formula (I), is described. The compound of formula (I) is a serum cholesterol lowering agent.