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USE OF MYB GENE TO DIAGNOSE AND TREAT T-CELL ACUTE LUMPHOBLASTIC LEUKEMIA
USE OF MYB GENE TO DIAGNOSE AND TREAT T-CELL ACUTE LUMPHOBLASTIC LEUKEMIA
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机译:MYB基因在诊断和治疗T细胞急性淋巴细胞白血病中的应用
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摘要
The present invention relates to the field of biotechnological means to diagnose or treat T-cell acute lymphoblastic leukaemia. More particularly, the invention relates to methods to diagnose T-cell acute lymphoblastic leukaemia via determining the presence of a duplication of the MYB gene in cells taken from patients. The invention further relates to inhibitors capable of neutralizing the biological activity of MYB alone, or in combination with inhibitors capable of neutralizing the biological activity of NOTCH1, which can be used to treat T-cell acute lymphoblastic leukaemia.
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