URINE BASED DETECTION OF A DISEASE STATE CAUSED OR EFFECTED BY PNEUMOCOCCAL INFECTION

摘要

There is provided a method of diagnosing a disease state in a subject. Thedisease state is caused or effected bypneumococcal infection. The method includes obtaining a biological test samplefrom the subject. The biological sample includes atleast one metabolite selected from the group consisting of citrate,trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate,glucose and carnitine. A respective concentration of each one of the at leastone metabolite is compared with a predeterminedconcentration value associated with a corresponding one of the at least onemetabolite. The predetermined concentration value isindicative of the disease state. For example, the biological sample includesany one of citrate, trigonelline, acetylcamitine, acetone,myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example,the biological samples include any combination ofcitrate, trigonelline, acetylcamitme, acetone, myo-xnositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, thebiological sample includes each one of citrate, trigonelline, acetylcamitinc,acetone, myoinositol, 3-hydroxybutyrate, glucose andcarnitine.