Method for controlled induction of somatic mutations and use thereof in proteomics

摘要

Inducing somatic mutations in vitro by treating cells (A), cultured in suitable medium, with a combination of anti-Ig (immunoglobulin) M antibodies (Ab1), and at least one of anti-CD21 antibodies (Ab2) and anti-CD19 antibodies (Ab3), is new. Ab1 are biotinylated and are subject to specific aggregation by streptavidin coupled to a carrier. An Independent claim is also included for a kit for the process comprising Ab1 and at least one of Ab2 and Ab3.