Use of peptides comprising post-translational modifications in the treatment of autoimmune pathologies

摘要

Use of peptides (I), containing epitopes (E) of mammalian self-proteins (II) that are recognized by antibodies produced by mammals suffering from autoimmune disease, also optionally by T helper cells, for preparing a composition for prevention or treatment of such diseases. At least one amino acid in (E) is post-translationally modified. An independent claim is also included for peptides (Ia) corresponding to the 131-151 amino acid region of the human or murine U1-70K protein and comprising the sequence Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-Ser-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr in which at least one amino acid is phosphorylated or acetylated. ACTIVITY : Immunosuppressive; Dermatological; Antiinflammatory; Antiarthritic; Antirheumatic; Neuroprotective; Antidiabetic. MECHANISM OF ACTION : Anti-DNA Antibodies Formation Inhibitor.