Method of selecting animal models from animals which have been subject to mutagenesis, and the use of Myb transcription factors for screening

摘要

The present invention relates generally to target molecules for potential therapeutic and/or prophylactic intervention. More particularly, the present invention provides a physiological assessment system in the form of vertebrate animal models to identify genetic or proteinaceous drug targets therein associated with a disease or a particular condition or phenotype. In an illustrative embodiment, target molecules associated with modulating platelet levels and ameliorating the symptoms of thrombocytopenia are described. The target molecules are useful as therapeutic and/or prophylactic agents such as in antisense or iRNA form. The present invention also relates to the application of these drug targets in the identification or development of therapeutic and/or prophylactic agents which modulate the functional activity of the drug target or its interacting network of molecules.