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Novel indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug each comprising the same
Novel indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug each comprising the same
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机译:用于使DNA的特定碱基序列烷基化的新型吲哚衍生物和烷基化剂以及各自包含该衍生物的药物
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摘要
There is provided a novel pyrrole-imidazole polyamide compound for alkylating the specific base sequence of DNA, the polyamide compound being capable of being synthesized through fewer reaction steps than known hybrid molecules and having a combination of a high reactivity in DNA alkylation and the ability to recognize a sequence. Furthermore, there is provided an alkylating agent and a molecule serving as a drug, the alkylating agent and the molecule containing the polyamide compound. An indole derivative is represented by general formula (1): wherein R 1 represents a functional group for alkylating DNA; R 2 represents a hydrogen atom, an alkyl group, or an acyl group; and X represents a divalent group having one constitutional unit or having two or more constitutional units which may be the same or different, the constitutional unit being represented by the following formula: (wherein m is an integer of 0 to 10), wherein among the constitutional units, a terminal constitutional unit adjacent to R 2 may be a constitutional unit represented by the following formula: (wherein k is an integer of 0 to 10).
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机译:提供了一种用于烷基化DNA的特定碱基序列的新型吡咯-咪唑聚酰胺化合物,该聚酰胺化合物能够通过比已知的杂化分子更少的反应步骤来合成,并且具有在DNA烷基化中的高反应性和脱氢的能力。识别序列。此外,提供了一种烷基化剂和用作药物的分子,该烷基化剂和包含聚酰胺化合物的分子。吲哚衍生物由通式(1)表示:其中R 1代表用于烷基化DNA的官能团; R 2表示氢原子,烷基或酰基。 X表示具有一个结构单元或具有两个以上相同或不同的结构单元的二价基团,该结构单元由下式表示:(其中m是0至10的整数),其中在构成单元中,与R 2相邻的末端构成单元可以是由下式表示的构成单元:(其中k是0到10的整数)。
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