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Small molecule inhibitors for MRP1 and other multidrug transporters
Small molecule inhibitors for MRP1 and other multidrug transporters
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机译:MRP1和其他多种药物转运蛋白的小分子抑制剂
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摘要
A method of potentiating the activity of a therapeutic drug, like a chemotherapeutic drug or an antibiotic, in a cell or tissue, by inhibiting the efflux capability of a multidrug transporter are disclosed. The method is useful in the treatment of a cancer by sensitizing tumor cells to a chemotherapeutic agent. Compounds capable of inhibiting an efflux capability of a multidrug transporter also are disclosed.
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