首页> 外国专利> PEPTIDES INTERACTING WITH ALPHA-HELICAL COILED-COIL STRUCTURES AND/OR COILED-COIL SEQUENCES, SUBSTANCES DERIVED THEREFROM, AND USE THEREOF

PEPTIDES INTERACTING WITH ALPHA-HELICAL COILED-COIL STRUCTURES AND/OR COILED-COIL SEQUENCES, SUBSTANCES DERIVED THEREFROM, AND USE THEREOF

机译:与α-螺旋盘绕结构和/或盘绕序列相互作用的肽,衍生自其的物质,并使用其

摘要

The invention relates to novel peptides for neutralizing and/or attaching to coiled-coil structures and associating with coiled-coil sequences, substances that are derived therefrom, and the use thereof, preferably for detecting, marking, and influencing coiled-coil structures and sequences in a biological or biotechnological system, particularly peptides of general formula (abcdefg)SUBn/SUB, wherein a to g represent amino acid radicals, among which a and/or d are hydrophobic while e and/or g are loaded, and n represents a number between 1 and 3, or fractions thereof that are composed of a minimum of 2 and a maximum of 15 amino acid radicals. The invention further relates to pharmaceutical compositions containing novel peptides and the use of such peptides for producing medicaments used for the treatment of HIV, influenza virus, or Mycobacterium tuberculosis infections.
机译:本发明涉及用于中和和/或附着于卷曲螺旋结构并与卷曲螺旋序列缔合的新型肽,由其衍生的物质及其用途,优选用于检测,标记和影响卷曲螺旋结构和序列在生物或生物技术系统中,特别是通式(abcdefg)n SUB的肽,其中a至g表示氨基酸基团,其中a和/或d是疏水的,而e和/或g是负载的,并且n代表1至3之间的数字,或其分数,其由最少2个和最多15个氨基酸基团组成。本发明进一步涉及含有新型肽的药物组合物,以及这种肽在生产用于治疗HIV,流感病毒或结核分枝杆菌感染的药物中的用途。

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