IN VITRO METHOD TO PREDICT THE TUMOR SENSITIVITY TO PHARMACOTHERAPY AND ENDORADIOTHERAPY

摘要

The present invention provides a method for the prediction of the sensitivity of malignant cells or malignant tissues to a cancer therapy which comprises the administration of a L-amino acid, conjugated to an alpha-, beta- or Auger-electron emitting isotope selected from the group consisting of bromine-76, bromine-77, bromine-82, iodine-123, iodine-124, iodine-125, iodine-131 and astatine-211 , wherein the L-amino acid is selected from the group consisting of phenylalanine, alanine, serine and cysteine. Moreover, the invention provides a pharmaceutical composition for an individual treatment of a malignant neoplasia and a kit for the prediction of the sensitivity of malignant cells or malignant tissues of an individual patient for such treatment. The invention also provides a use of one or more L-amino acid(s) selected from the group consisting of phenylalanine, alanine, serine and cysteine, conjugated to an alpha-, beta- or Auger-electron emitting isotope selected from the group consisting of bromine-76, bromine-77, bromine-82, iodine-123, iodine-124, iodine-125, iodine-131 and astatine-211 , for the preparation of a pharmaceutical composition for an individual patient for the treatment of malignant neoplasia, wherein for the selected one or more L-amino acid(s) a sensitivity of the malignant cells or malignant tissues from the individual patient is predicted by the method of the invention and a method for the individual treatment of a patient suffering from malignant neoplasia.