首页> 外国专利> LIPOSOMAL COMPOSITION OF ANTIOXIDANTS FOR INHALATIONS CARRIED OUT DURING LUNG AND UPPER RESPIRATORY TRACT DISEASES

LIPOSOMAL COMPOSITION OF ANTIOXIDANTS FOR INHALATIONS CARRIED OUT DURING LUNG AND UPPER RESPIRATORY TRACT DISEASES

机译:肺和上呼吸道疾病中吸入的抗氧化剂的脂质体组成

摘要

The invention relates to medicine and pharmacology, in particular to liposomal composition of antioxidants suitable for inhalations during lung and upper respiratory tract diseases. The inventive antioxidant composition for inhalations of lungs and upper respiratory tracts is embodied in the form of an emulsion of phospholipides in the form of liposomes, the mean size of the particles of which ranges from 0.2 to 0.4 mkm, wherein dihydroquercitin flavonoid and wheat-germ oil, containing hydrophobic tocopherol antioxidants (vitamin E) and carotinoids, are incorporated in the membranes of said particles and the aqueous phase of the emulsion contains potassium chloride and antioxidants in the form of a cevitamic acid (vitamin C), N-acetyl, L-cystein and potassium bensoate. Said antioxidant composition is selected taking into account the possibility of introducing minimum doses of individual vitamins in such a way that the content of an active unoxidised form of antioxidants is not reduced during storage.
机译:本发明涉及医学和药理学,尤其涉及适用于在肺和上呼吸道疾病期间吸入的抗氧化剂的脂质体组合物。用于吸入肺和上呼吸道的本发明抗氧化剂组合物以脂质体形式的磷脂乳液的形式体现,其颗粒的平均尺寸为0.2至0.4mkm,其中二氢槲皮素类黄酮和小麦胚芽将包含疏水性生育酚抗氧化剂(维生素E)和类胡萝卜素的油掺入所述颗粒的膜中,并且乳液的水相包含氯化钾和抗氧化剂(鲸蜡酸(维生素C),N-乙酰基,L -半胱氨酸和苯磺酸钾。选择所述抗氧化剂组合物时考虑了引入最小剂量的单个维生素的可能性,使得在储存期间不降低活性未氧化形式的抗氧化剂的含量。

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