Detection of HPV-induced invasive cancers and their precursor lesions with invasive potential

摘要

The invention is in the field of medicine and is concerned with a molecular diagnostic marker for HPV-induced invasive cancers and their precursor lesions with invasive potential. In particular the present invention relates to the use of the TSLC1 gene as marker for invasive cervical cancer. The invention provides methods for detecting HPV-induced invasive cancers and their precursor lesions associated with tumor suppressor lung cancer 1 (TSLC1), comprising contacting a target cellular component of a test cell with a reagent that detects TSLC1 and detecting a reduction in the TSLC1 as compared to that of a comparable normal cell. The invention also provides molecular diagnostic markers for premalignant cervical lesions with invasive potential associated with tumor suppressor lung cancer 1 (TSLC1) in cytologically abnormal cervical smears and/or biopsies.