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DIHYDROPYRIDAZINE, TETRAHYDROPYRIDINE, CHROMANONE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS HEAT-SHOCK PROTEIN 90 INHIBITORS
DIHYDROPYRIDAZINE, TETRAHYDROPYRIDINE, CHROMANONE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS HEAT-SHOCK PROTEIN 90 INHIBITORS
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机译:二氢吡啶类,四氢吡啶类,色曼酮和二氢萘醌类作为热激蛋白90抑制剂
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摘要
Disclosed are compounds and pharmaceutically acceptable salts of Formula (I), wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula (I) are heat-shock protein 90 (HSP-90) inhibitors, useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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