Extract of baobab fruit and Hibiscus calix to inhibit expression of sirtuins in epidermal cells at very low dose of few thousandths of percent and inhibit contraction of muscle fibers while stimulating e.g. heat-shock protein-90 expression

摘要

Extract of baobab fruit and Hibiscus calixfor the preparation of a cosmetic, pharmaceutical and dermo-cosmetic composition to inhibit the expression of sirtuins in epidermal cells at very low dose of few thousandths of percent and inhibit the contraction of muscle fibers at doses of a few percents while stimulating the expression of claudine-1 epidermal protein and heat-shock protein-90, is claimed. ACTIVITY : Dermatological. MECHANISM OF ACTION : Sirtuin-1 expression inhibitor. The ability of (I) to inhibit sirtuin-1 expression was tested using epidermal cells (keratinocytes). The result showed that the dry extract of native baobab fruit (at a concentration of 0.008%) reduced the expression of sirtuin (SIRT-1) epidermal cells (keratinocytes) of 55%.