Extract of Hibiscus calix and epicalyx to inhibit expression of sirtuins in epidermal cells at very low dose of few thousandths of percent and inhibit contraction of muscle fibers at doses of few percents while stimulating NICE-1

摘要

Extract of Hibiscus calixand epicalyx for the preparation of a cosmetic, pharmaceutical and dermo-cosmetic composition to inhibit the expression of sirtuins in epidermal cells at very low dose of few thousandths of percent and inhibit the contraction of muscle fibers at doses of a few percents while stimulating nisin-controlled gene expression (NICE-1), is claimed. ACTIVITY : Dermatological. MECHANISM OF ACTION : Sirtuin expression inhibitor; Nisin-controlled gene expression stimulator. The ability of (I) to inhibit sirtuin-1 expression was tested using epidermal cells (keratinocytes). The result showed that the native dry extract of Hibiscus calix(at a concentration of 0.004%) reduced the expression of a sirtuin-1 of epidermal cells (keratinocytes) of 52%.