首页>
外国专利>
BLOCKADE OF AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN A MURINE MODEL OF ASTHMA BY INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3)
BLOCKADE OF AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN A MURINE MODEL OF ASTHMA BY INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3)
展开▼
机译:胰岛素样生长因子结合蛋白3(IGFBP-3)在哮喘小鼠模型中对气道高反应性的阻塞和炎症
展开▼
页面导航
摘要
著录项
相似文献
摘要
The physiological role of IGFBP-3 in respiratory inflammation and hyperresponsiveness is presently unknown. The present invention is based on the unexpected finding that both wild-type IGFBP-3 and the IGFBP-3 mutant GGG-IGFBP-3 inhibit tissue inflammation and hyperresponsiveness associated with obstructive respiratory disorders such as bronchial asthma. Provided herein are methods of treating obstructive respiratory disorders and various conditions associated with airway hyperresponsiveness, including asthma, by administering recombinant IGFBP-3 or IGFBP-3 mutants or vectors encoding IGFBP-3 or IGFBP-3 mutants.
展开▼