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USE OF THE PROTEIN KINASE C INHIBITOR TAMOXIFEN FOR THE TREATMENT OF BIPOLAR DISORDER
USE OF THE PROTEIN KINASE C INHIBITOR TAMOXIFEN FOR THE TREATMENT OF BIPOLAR DISORDER
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机译:蛋白质激酶C抑制剂他莫昔芬在治疗双歧疾病中的应用
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Bipolar subjects with manic/mixed episode were randomly assigned to receive either tamoxifen (80mg/day) or identical placebo tablets in 1:1 ratio for three weeks. At the end of three weeks of trial tamoxifen treatment has been shown to have strong anti-manic properties. Protein kinase C inhibition seems to be one of the direct targets of lithium and valproate, The existing effective treatments in bipolar disorder/mania. These findings may lead to delineation of the underlying pathophysiology of bipolar disorder and development of novel therapeutics.
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