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COASTER, A HUMAN COACTIVATOR OF STEROID RECEPTORS
COASTER, A HUMAN COACTIVATOR OF STEROID RECEPTORS
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机译:COASTER,类固醇受体的人类激活剂
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摘要
The invention provides a protein having an amino acid sequence as in SEQ ID 7, 8, 11 or 12, similar proteins, naturally occurring variants and homologous functional equivalents thereof, as well as the use of a polynucleotide encoding such protein, for use in an assay and for use in a method of modulation of transcriptional activity promoted by a responsive nuclear receptor and a coactivator, which coactivator is the mentioned protein and is named COASTER, and which nuclear receptor is preferrably a steroid receptor.
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机译:本发明提供了具有如SEQ ID 7、8、11或12的氨基酸序列的蛋白质,类似的蛋白质,其天然存在的变体和同源功能等价物,以及编码该蛋白质的多核苷酸的用途,用于检测和用于调节由反应性核受体和共激活剂促进的转录活性的方法,该共激活剂是提到的蛋白质,被称为COASTER,并且该核受体优选是类固醇受体。
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