10 Multimeric Coactivator Complexes for Steroid/Nuclear Receptors

摘要

Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand-binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone-modifying activities or through other novel functions. In addition, other ligand-recraited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcrip-tional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters.