USE OF AN ANIMAL MODEL AND METHOD FOR TESTING DRUGS AND TREATMENTS FOR CANCER IN HUMANS

摘要

The present invention relates to the use of a non-human animal in an animal model for studying cancer and/or for assaying novel treatments and drugs for treating cancer in humans, which animal has an alteration in its genome as compared to the wildtype animal, which alteration leads to a modified expression of Aph-1b. The alteration comprises for example the presence of only one copy of the Aph-1b gene as compared to two copies in the wild type genome or the presence of the SNP651 TG mutation in the said gene.