NONINVASIVE METHOD TO IDENTIFY NEUROACTIVE COMPOUNDS AND MEASURE THEIR PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES

摘要

Embodiments of the present invention provide for the physiological analysis of neuroactive compounds in vivo and provide a unique mechanism for deriving pharmacokinetics and pharmacodynamics. Embodiments of the present invention take advantage of the recognition that the amplitude and/or phase of oscillatory potentials (OPs) of electroretinograms (ERGs) may be affected by systemic administration of various compounds. As a result, embodiments of the present invention provide screening methods and assays to determine the neural impact and efficacy of various drugs in individual animals, including humans.